Defraggler will run on any PC running Microsoft Windows XP or later. If you're running one of the following operating systems, you're set to run Defraggler:
Defraggler is a small, efficient program, so there are no minimum memory or hard drive requirements.
Note 1: Defraggler can defrag NTFS and FAT hard drives, as well as exFAT format USB drives. We do not recommend that you defrag USB drives that have not been formatted as exFAT. Generally, they will not benefit by being defragmented and theoretically defragging can shorten their lifespan.
Since the data on CDs and DVDs is read-only, you cannot defrag these drives either.
Note 2: For Windows 2000 we recommend Defraggler Version 1.
Note 3: Defraggler does not currently support Mac OS X or Linux.